Methusalife - RNA/DNA Bases with Co-Factors
Tired of feeling your age? Methusalife is a natural,
caffeine-free boost for physical and mental energy. It also
provides the building blocks for healthy cells with anti-aging
support and it comes in a convenient liquid, spray form.
Metabolism of DNA and RNA Five
nucleic acid bases make up the information code of life. Both
DNA and RNA share three of the bases -adenine, guanine, and
cytosine. In DNA, the fourth base is thymine, whereas in RNA it
is uracil. In DNA, each base combines with a five-carbon sugar
called deoxyribose, hence the term DNA stands for
deoxyribonucleic acid. In RNA, each base combines with the
five-carbon sugar ribose, thus RNA stands for ribonucleic acid.
The information code in DNA in the cell nucleus is transcribed
to b>RNA, which is then translated to all the enzymes and
proteins made in the body. The DNA to b>RNA to protein
translation mechanism makes possible the vast diversity of life
When DNA and RNA are ingested intact, they are
intensely metabolized by intestinal bacteria and the intestinal
lining. Over 95% of the pyrimidines bases cytosine, thymine, and
uracil are degraded by the intestinal lining before reaching the
blood stream. Only about 3% of the pyrimidines make it to the
liver for further use in the body. The fate of the purine bases
adenine and guanine is even more extreme. Over 99% of the
purines are broken down to uric acid before being absorbed into
the bloodstream. Therefore only a tiny fraction of ingested DNA
or RNA becomes available for the numerous functions required of
them throughout all the cells of the body. In addition to
ingested DNA and RNA elements, the body can make DNA and RNA
bases from simpler nutrients in the diet. In particular, the
amino acids glycine, glutamine, serine, and aspartic acid, along
with vitamin cofactors are used to make DNA and RNA bases from
scratch. In order to make nucleic acids from simpler substances
requires having all of the precursors and cofactors in adequate
amounts at the time of production. In addition, it requires
having sufficient amounts of numerous enzymes in the correct
proportions and locations in the cell.
Recent evidence indicates
that the body is often not able to make enough DNA and RNA to
protect, repair, and regenerate cells to their optimum function.
This is especially true for cells that have high turnover rates
such as the intestinal lining that may fully replace itself
every week. The demand for production may particularly exceed
synthetic capacity under conditions of stress in which the
demand for greater cell activity and function becomes acute,
particularly for the dynamic populations of cells in the immune
system. When demand exceeds production capacity, DNA and RNA
base components become essential nutrients for protecting and
preserving health. Numerous lines of evidence will be presented
to show the far reaching health benefits of supplementing DNA
and RNA during health stresses and even for general well being
Table of Contents
In this era of an increasingly enlightened public about the health benefits
of nutritional supplements, there is a new area perhaps more overlooked than
any other. This central area of health and nutrition is the ingestion of
dietary nucleic acid bases - the essential building blocks of DNA and RNA.
The main reason these highly important nutrients have been neglected is that
the body is able to manufacture nucleic acid bases from amino acids and other
basic nutrients. In general, if the body can make a substance from other
nutrients that substance has not been considered essential. However, under
certain conditions, the body is not able to make enough DNA and RNA bases
to support the needs of the body's tissues and organs, with a drastic reduction
in the potential for health.
Numerous studies in animals and humans show dramatic benefits in health,
function, and survival with the supplementation of nucleic acid elements.
These effects are so powerful that survival in life threatening assaults
ranging from radiation to infection to shock has been markedly increased.
From the standpoint of longevity studies, no single method has increased
longevity more than supplementing DNA and RNA elements.
Methusalife DNA/RNA is thus one of the most rejuvenating, immune enhancing,
and tissue supporting formulas ever to be released. The wide-ranging benefits
to be described are further boosted with a proprietary globally patented
laser technology that significantly increases the efficiency of nutrient
utilization, making for an unmatched product that cannot be duplicated.
Table of Contents
1. Metabolism of DNA and RNA
2. Advantages of Oral Spray Delivery System
3. Research Studies with Supplemental DNA
C. Radiation Injury
D. Tissue Regeneration
E. Wound Healing
F. Endocrine Gland Repair
G. Intestinal Integrity, Maturation, and
H. HDL Cholesterol Levels
I. Growth and Development
J. Cellular Immunity
K. Memory Enhancement
5. Laser Enhancement Technology
6. DNA/RNA Precursor Support
7. Longevity Enhancing Cofactors
8. Added ATP Benefits
A. Cellular Energy
B. Neurologic Effects
C. Cardiac Strengthening
D. Muscle Performance
E. Lung Function
F. Cellular Immune Enhancement
G. Antitumor Effects
H. Improved Human Survival of Shock
I. Sexual Function
10. Summary and Conclusion
1. Metabolism of DNA and RNA
Five nucleic acid bases make up the information code of life. Both DNA and
RNA share three of the bases -adenine, guanine, and cytosine. In DNA, the
fourth base is thymine, whereas in RNA it is uracil. In DNA, each base combines
with a five carbon sugar called deoxyribose, hence the term DNA stands for
deoxyribonucleic acid. In RNA, each base combines with the five-carbon sugar
ribose, thus RNA stands for ribonucleic acid.
The information code in DNA in the cell nucleus is transcribed to RNA, which
is then translated to all the enzymes and proteins made in the body. The
DNA to RNA to protein translation mechanism makes possible the vast diversity
of life on earth.
When DNA and RNA are ingested intact, they are intensely metabolized by
intestinal bacteria and the intestinal lining. Over 95% of the pyrimidines
bases cytosine, thymine, and uracil are degraded by the intestinal lining
before reaching the blood stream. Only about 3% of the pyrimidines make it
to the liver for further use in the body. The fate of the purine bases adenine
and guanine is even more extreme. Over 99% of the purines are broken down
to uric acid before being absorbed into the bloodstream. Therefore only a
tiny fraction of ingested DNA or RNA becomes available for the numerous functions
required of them throughout all the cells of the body.
In addition to ingested DNA and RNA elements, the body can make DNA and RNA
bases from simpler nutrients in the diet. In particular, the amino acids glycine, glutamine, serine, and aspartic acid, along with vitamin cofactors
are used to make DNA and RNA bases from scratch.
In order to make nucleic acids from simpler substances requires having all
of the precursors and cofactors in adequate amounts at the time of production.
In addition, it requires having sufficient amounts of numerous enzymes in
the correct proportions and locations in the cell.
Recent evidence indicates that the body is often not able to make enough
DNA and RNA to protect, repair, and regenerate cells to their optimum function.
This is especially true for cells that have high turnover rates such as the
intestinal lining that may fully replace itself every week. The demand for
production may particularly exceed synthetic capacity under conditions of
stress in which the demand for greater cell activity and function becomes
acute, particularly for the dynamic populations of cells in the immune system.
When demand exceeds production capacity, DNA and RNA base components become
essential nutrients for protecting and preserving health. Numerous lines
of evidence will be presented to show the far reaching health benefits of
supplementing DNA and RNA during health stresses and even for general well
being and longevity.
2. Advantages of Oral Spray Delivery System
Methusalife DNA/RNA is provided as a highly convenient and biologically active
oral spray formula. Providing the nucleic acid base components in this form
can increase their absorption into the bloodstream highly significantly.
Instead of only 1-3% delivery to the blood stream for systemic use, the oral
spray may effectively deliver 90% or more of the nucleic acids ingested to
cells and tissues throughout the body.
It is very important to make the distinction between chains of DNA and the
individual bases of DNA. Intact DNA strands are long chains of individual
bases strung together into a double helix that may have over 10 million bases
linked together into a single enormous molecule. Intact DNA strands provide
a linear code for the production of proteins and enzymes. Therefore intact
strands of DNA bases are information containing and have a small but real
potential for influencing DNA information in the cell nucleus. Long chains
of DNA require extensive digestion to extract individual bases, resulting
in poor absorption and only a small fraction of the bases being available
for the body to use.
In contrast, the individual bases of DNA do not give sequence information.
They are simply building blocks, much as the letters of the alphabet are
the building blocks for words. Their small molecular size makes them highly
and rapidly absorbable, greatly increasing their ability to be assimilated
and used in cells and tissues throughout the entire body. They are nutritional
and not informational. They are very safe and help the body repair and rebuild
the DNA and RNA needed for health and cell regeneration. Methusalife DNA/RNA
only contains the individual bases of DNA and RNA for safety and a high potency
of absorption and utilization.
3. Research Studies with Supplemental DNA and RNA
Numerous published scientific studies indicate very significant health benefits
from DNA and RNA component supplementation. Almost every system of the body
has documentation of improved health, vitality, or function from providing
supplements of these fundamentally important cellular elements, from infancy
to advanced age. The following is a brief summary from the vast literature
supporting the many published benefits of the components of Methusalife DNA/RNA.
Staph aureus is one of the most aggressive bacterial infections faced in
medical treatment. It tends to cause deep-seated abscess forming infections,
often associated with extensive tissue destruction, high fever, and resistance
to treatment. Surgical drainage is often required to clear pockets of infection.
Without surgery, antibiotics alone are often ineffective at eradicating this
invasive pathogen. Epidemics of Staph aureus resistant to all antibiotics
have become a devastating problem in hospitals and treatment centers around
A study in mice was performed to assess the ability of supplemental nucleic
acid components to modify the course of virulent Staph aureus infection.
The control animals that received no additional RNA or DNA elements showed
a raging 71% mortality. In contrast, the animals that were supplemented with
nucleic acid bases by injection showed vastly reduced mortality to 21%.
Candida is a form of yeast that frequently causes infections in humans. If
Candida gets into the human bloodstream and persists, medical complications
and mortality tend to be very significant. In experimental blood borne Candida
infections in mice, the nucleic acid supplemented animals had a much higher
survival rate than the untreated control animals.
These experiments suggest that supplemental DNA and RNA bases given in a
form with absorption comparable to injection may strengthen the body to combat
serious infections. This is likely to occur through improved immune function,
although factors related to generally strengthening the vitality of tissues
may also be a factor.
The very high absorbability of Methusalife DNA/RNA by oral spray is designed
to support the immune system and general tissue vitality with a high degree
of potency. Such supplemental support can help provide an added measure of
resilience to sustain health or recover from infection.
A study in mice assessed whether RNA supplementation improved survival from
an aggressive cancer. The animals received a tumor vaccine and then transplants
of a tumor cell line. The animals that only received the tumor vaccine all
died within three weeks. In sharp contrast, the animals that received a single
2mg injection of RNA after the tumor vaccine had a 40% long-term survival.
Thus the support of an antitumor program with only a tiny single dose of
RNA provided a dramatic improvement in survival and outcome.
3C. Radiation Injury
Ionizing radiation causes intense free radical generation and molecular
fragmentation; the greater the intensity and dose, the greater the harm that
occurs to all exposed tissues. The greatest harm tends to occur to cells
that are dividing the most rapidly. Radiation is often used for cancer treatment
because the tumor cells are more sensitive to radiation than the more slowly
dividing normal cells; however, all the cells in the beam path sustain dose
In a study in mice to determine the protective effects of nucleic acid
supplementation, all the animals were exposed to a very high dose of radiation.
The survival rate in the control animals was extremely low at 5%. In contrast,
the animals that received nucleic acid injections had vastly improved survival
- ten times higher at 50%.
This suggests a generally strongly protective effect of nucleic acid supplements
for all forms of ionizing radiation exposure, whether therapeutic or accidental.
Even persons who use airline travel regularly may benefit from protecting
their cells from the relatively higher exposure that tends to occur at altitude.
3D. Tissue Regeneration
In order to sustain health, virtually every tissue in the body must regenerate
itself regularly. It is now known for example that even neurons in the brain
have the capacity to regenerate. Having adequate supplies of all the nucleic
acid bases may be one of the most significant limiting factors on whether
a tissue will be able to express its greatest capacity for regeneration and
A study in rats looked at the ability of the liver to regenerate depending
on whether or not injections of nucleic acid bases were given. In this study,
the rats had 70% of their livers surgically removed. The animals that received
IV nucleic acids showed liver regeneration rates that were significantly
greater than the untreated control animals.
Any tissue, in order to regenerate, requires the ability to make DNA and
RNA to support the process of making new cells. Providing readily absorbed
and assimilated DNA and RNA bases can be one of the most powerful ways to
assist any tissue to repair and renew itself.
3E. Wound Healing
A wound, surgical or otherwise, results in severing the usual integrity of
tissue organization. It is a special case of tissue regeneration in which
cells migrate into the area of the wound to either regenerate new tissue
or to fill the defect with scar tissue. The type of healing depends on the
tissue - the liver will tend to restore normal liver cells in the wound,
whereas the skin will tend to fill the breach with scar to heal the opening
and restore strength.
Several studies in wound healing have assessed the effects of supplemental
nucleic acids on wound healing, especially of surgical wounds. Compared to
the control group, those receiving the supplements showed more rapid healing,
greater tensile strength of the skin, and significantly reduced scarring.
3F. Endocrine Gland Repair
Some of the tiniest organs in the body have the most profound effects on
our health and well being. These are the endocrine glands that secrete minute
amounts of hormones into the blood without which every function of the body
The tissues that are most susceptible to reduced function from nucleotide
deficiency have been found to extract high proportions of nucleic acids from
blood. These studies have examined the relative amounts of nucleic acid bases
a tissue will incorporate if the nucleic acids are given through the GI tract
versus being given intravenously.
The incorporation level of the administered nucleic acid bases is measured
by giving nucleic acids that have been labeled with a radioactive marker.
The amount of radioactivity measured in a tissue when it is given through
GI absorption versus IV delivery then gives the assimilation ratio of the
two routes of administration. Highly metabolically active tissues that are
the most sensitive to stress-induced nucleic acid deficiency are those that
have the highest IV: GI assimilation ratios.
In animal studies, the highest IV: GI assimilation ratios were found in the
vitally important pituitary, thymus, thymus, salivary, and adrenal glands.
The measured ratios ranged from 29-59:1 for IV delivery versus GI absorption.
Other dynamic tissues that showed similarly high ratios were the intestinal
lining and the lymphoid tissue of the immune system.
The pituitary gland located at the base of the skull has been called the
"master gland" because it makes hormones that control the functions of other
endocrine glands. It secretes hormones that regulate the thyroid and adrenal
glands, the ovaries and testes, and the production of breast milk. The posterior
region of the gland exerts control over the kidneys to adjust fluid balances
throughout the body. Perhaps most important for longevity, the pituitary
also makes growth hormone, that has been shown to have some of the most powerful
age-reversing effects of any hormone ever studied. Inadequate nutritional
support to this gland can have devastating and far-reaching effects throughout
The adrenal glands, situated atop the kidneys, secrete adrenaline and
noradrenaline, the fight or flight hormones. These powerful hormones increase
heart rate and blood flow to muscle so that the body is immediately prepared
for vigorous physical activity. In our ancestral past, this rapid preparation
was a key to surviving in a hostile environment. However, modern living often
puts a chronic stress on the adrenal glands, the myriad stimuli that surround
us tending to keep the fight or flight mechanism constantly activated. The
result is often varying degrees of adrenal burnout, exhausting the reserves
of the gland to make the fight or flight hormones when really needed. Burned
out adrenals give rise to a chronic low energy state, fatigue, and poor stress
tolerance, like depleted batteries that fail to get recharged. These glands
are especially prone to nucleotide deficiency under chronic stress, a condition
that Methusalife DNA/RNA can help to restore, much as giving a long needed recharge
to a nearly totally drained battery.
The thymus gland, residing behind the breastbone, is often considered the
organ of rejuvenation and longevity. It is the gland in which the T cells
of the immune system are formed and given identity. Upon release it is the
T cells in particular that help find and destroy cancer cells and cells that
have become afflicted with viruses. The thymus gland tends to shrink with
time, yet specific supplementation has been found to bring this vital organ
back to more youthful function. In particular, providing nucleic acid bases
for this gland with very dynamic cell turnover can significantly rejuvenate
this gland and its life preserving activities.
The thyroid gland, at the base of the neck in front of the windpipe, produces
thyroid hormones, the main control mechanism for setting basal metabolic
rate. In some circles it is believed that we are in the midst of an epidemic
of undetected deficiency of thyroid function. Tests of thyroid function may
not show overt clinical disease, but low-level deficiency can significantly
reduce quality of life. Effects are subtle and can include generally low
energy, sluggish bowel function, lack of initiative, tendency to depressed
mood, and weight gain with great difficulty losing the added pounds. Dietary
iodine and the amino acid tyrosine are important building blocks to make
thyroid hormone naturally from the gland. In addition, correcting insufficient
nucleic acid production under stress will also support recovery of a sluggish
The salivary glands reside in several pockets in the mouth. Although not
as essential as the other glands to sustain life, they provide a vital role
in the first stages of preparing food for complete digestion. These metabolically
active glands also require a rich supply of nucleic acids to maintain adequate
Methusalife DNA/RNA can thus be a very powerful tonic to sustain and boost the
functions of the most vital glands in the body. These glands set our level
of energy, our ability to respond to stress, our capacity to maintain strong
immune defenses, the hydration of our bodies, and a wide range of hormone
balances essential to a high quality of life.
3G. Intestinal Integrity, Maturation, and Bowel Flora
The intestinal lining replaces all of its cells every seven days. Only a
single layer thick, this lining is highly dependent on a sufficient supply
of nucleic acids to completely regenerate itself every week. If nutritional
support is inadequate, defective regeneration of the intestinal mucosal lining
impairs the enzymatic stages of digestion, which can lead to a vicious cycle
of deteriorating digestion and nutritional status.
In a study in young rats with chronic diarrhea, the effects of nucleic acid
supplementation was tested. In the untreated animals the intestinal villi,
finger-like absorptive projections, showed a dramatic reduction in height,
like a forest that had been chopped down to stumps. The intestinal lining
cells showed a drastic reduction of digestive enzymes, the essential final
step of digestion that breaks nutrients down to the building block levels
that the body can use. These animals were clearly failing to thrive. Upon
administration of supplemental nucleic acids, the appearance of the intestinal
lining greatly improved, with regeneration of the height of the absorptive
intestinal villi. In addition, the enzyme content and function of the intestinal
lining also greatly improved, permitting the animals to recover and thrive
Human infants also require dietary nucleotides for optimum health, development,
and well-being. Human breast milk has a significantly higher content of certain
nucleic acid bases than does cows milk. Infants fed formula milk instead
of breast milk have been found to have pathological intestinal bacteria that
greatly increases their risk of outbreaks of diarrhea; especially in developing
countries, such outbreaks can be life threatening.
Studies have shown that if formula milk is supplemented with a nucleic acid
profile similar to that in breast milk, infants thus fed have a much healthier
profile of intestinal bacteria, typical of infants that have actually been
breast fed. In the nucleic acid supplemented infants, the incidence and severity
of diarrhea is reduced significantly to the level seen in breast fed infants.
One of the most vital components of breast milk that confers its health and
developmental advantages over formula milk thus appears to be its higher
content of nucleic acids, making a strong case for such supplementing of
all formula milk.
3H. HDL Cholesterol Levels
An additional finding in infants who received nucleic acid supplementation
was an improvement in their blood lipid profiles. In particular, the infants
receiving added nucleic acids were found to have higher HDL cholesterol levels,
the cholesterol fraction that protects against cardiovascular disease the
higher the level. It is possible that establishing higher HDL levels early
in life may confer an ongoing tendency to cardiac protection.
3I. Growth and Development
Studies in young laboratory animals have assessed the effects of supplementing
DNA and RNA elements. Compared to control animals, the supplemented animals
grew, developed, and increased muscle mass at a greater rate. Other vital
proteins were also built more readily in the treated animals. The intestinal
lining in particular matured more robustly in the supplemented animals. Research
thus far indicates that the tremendous need for nucleic acids in growth and
development is strongly beneficially supported through supplementing these
vital nutritional elements.
3J. Cellular Immunity
Cellular immunity refers in particular to immune cells that have the role
of identifying cells in the body that have become abnormal, so that the abnormal
cells can be removed. The main cellular changes sought through the cellular
immune system are the development of cancer cells or various types of
intracellular infection. The goal of the cellular immune system is to eliminate
cancer cells or infected cells before they can become established in the
body to cause serious illness.
The main effectors of cellular immunity are cells that arise in the thymus
gland. These cells are often called T cells for their thymic derivation,
of which there are several types with varying functions. A special type of
T cell called a cytotoxic T cell has the role of finding and sticking to
abnormal cells, then releasing substances that selectively digest and clear
the renegade cells.
Whereas cytotoxic T cells are generally active in seeking and clearing a
wide range of abnormal cells, natural killer cells have a more targeted mission:
seeking and destroying any cell that has become a cancer cell. The integrity
of cellular immune function, most especially natural killer cell function,
is the first line of defense of preventing tumor cells from establishing
a stronghold in the body. Many studies have correlated reductions of cellular
immune and natural killer cell function with increasing risks of developing
cancer; some scientists feel that cancer is primarily a problem of inadequate
Cytotoxic T cells, natural killer cells, and other types of T cells are also
known as lymphocytes. These cells are a major component of the body's lymphoid
tissues that protect us from infections and cancers of many types. In addition
to the T cells of several types there are also B cell lymphocytes whose role
is the production of antibodies. Unlike T cells that act directly cell-to-cell,
antibodies are released into the bloodstream to hunt down specific infectious,
toxic, or tumor cell molecules. Lymphoid tissues that coordinate the functions
of the immune system include the spleen, tonsils, lymph nodes, Peyer's patches
widespread throughout the intestines, regions of the bone marrow, and most
importantly the thymus gland.
The lymphoid tissue and especially cellular immunity has been found to be
highly vulnerable to nucleic acid depletion under conditions of stress. In
other words, at the time of greatest need for protection, inadequate supplies
of DNA and RNA bases can weaken the ability of the body to respond to the
threat. An insult or tumor or infection the body might otherwise easily handle
can escape control if the lymphoid does not have adequate nutrition to respond.
Numerous studies in animals and humans have shown that supplementing nucleic
acid elements has profoundly beneficial effects on boosting the function
of lymphoid tissue. In part, the reason for this is that lymphoid tissue
is highly dynamic such that cells that have become sensitized to microbial
invaders or cancer cells need to divide rapidly to make an army of specifically
targeted cells to eliminate the invader. A rich supply of nucleic acids,
often beyond that the body can readily make, may be required for all the
activities required for expanding the cells that prevent a minor invasion
from becoming an overwhelming infection or uncontrolled malignancy.
Published studies have particularly demonstrated that cellular immunity is
significantly strengthened with nucleic acid supplementation. Research that
has examined natural killer cell function has shown especially dramatic effects
on increasing the activity and function of these tumor surveillance and
elimination cells. Improved health of body tissues in general and enhanced
cellular immunity in particular, likely accounts for the vastly improved
outcomes observed in the face of a wide range of minor to life threatening
3K. Memory Enhancement
It is not generally well recognized that forming long-term memories requires
significant quantities of nucleic acids. Especially the availability of an
adequate pool of RNA is needed to manufacture new proteins that are essential
to memory function. Although other support nutrients are an important factor,
optimum memory function is not possible without a rich supply of nucleic
Many studies in animals and humans have found a dramatic improvement in memory
function with nucleic acid supplementation. Whether it is the ability to
remember the right pathway to get through a maze for a prize of cheese, or
to remember facts and figures, giving supplements of DNA and RNA elements
has highly significantly increased performance.
Perhaps most dramatically, one researcher has focused on giving nucleic acids
to persons with dementia. Even with advanced cases, if he went to high enough
delivery levels to his patients, in almost every case memory improvement
was very significant. The doctor reported that even in advanced cases of
dementia dramatic memory recovery occurred if high enough levels of nucleic
acids were given.
It is perhaps functional nucleic acid deficiency that limits our potential
for healthy longevity more than any other single factor. Of all the interventions
that have ever been attempted to increase the life span of mammals, no method
ever studied has been more powerful for mammalian life extension than nucleic
acid supplementation. Compared to other techniques that have increased longevity
of experimental animals up to 50%, administering nucleic acids has doubled
and even tripled the usual maximum life span.
In a landmark study, a strain of rats was used that had a usual life span
of 800-900 days. The study began with all of the animals at day 750, rather
advanced in age at the entry of the test protocol. Half of the animals were
used as controls and received their standard diet, housing, and care. The
treatment group animals were given identical conditions with the exception
of receiving weekly injections of DNA and RNA.
After eight weeks the control rats looked much worse than at the start of
the study, losing fur and muscle mass, and showing reduced physical activity.
In sharp contrast, at this time in the study, the treated animals actually
looked and behaved like younger animals. They regrew fur and increased their
muscle mass, had renewed libido, and were significantly more active.
By day 150 of the study, all of the untreated control animals had died. In
dramatic contrast, the minimum additional life span in the treated animals
was 850 days, minimally doubling the usual life span of the animals. Perhaps
most noteworthy, the longest lived animal in the treatment group survived
1500 days from the start of the study.
This is the greatest life extension ever reported for a mammal; nearly triple
the usual maximum life span. It is especially remarkable because the animals
were of advanced age at the start of the study. Weekly injections of DNA
effectively increased the remaining life spans of the animals by 500-900%.
It is as yet unknown whether even greater degrees of life extension could
be achieved by beginning nucleic acid supplementation at an even earlier
age, before any organ deterioration had occurred. It is likely that the longevity
achieved would be at least as great or greater.
It is important to note that the doubling and tripling of the animal's life
span resulted from an ongoing program of nucleic acid delivery. This suggests
that optimum longevity effects from DNA and RNA component supplementation
requires continuous delivery of nucleic acid bases; this assures that the
major glands and tissues of the body always have the elements needed for
peak rejuvenation and repair.
Methusalife DNA/RNA provides the most concentrated, efficient, and cost effective
delivery of nucleic acids ever developed. For cell rejuvenation, enhanced
immunity, and numerous tissue benefits, the oral spray of this formula provides
readily absorbed pure individual nucleic acid bases. The magnitude of this
delivery is indicated by the quantity of DNA nucleic acid base elements given
in a single one-month supply of Methusalife DNA/RNA - nearly double the amount
of all the nuclear DNA in all the cells of the body.
7. Longevity Enhancing Cofactors
To make Methusalife DNA/RNA an ultimate anti-aging formula, it also provides
clinically tested nutrients that can reverse the aging clock at the DNA level.
These nutrients have also been shown to protect and repair DNA and prevent
DNA mutations, thus reducing the risk of cancer and preserving cells at a
more youthful level.
Perhaps the primary mechanism of aging in the cells is the loss of DNA markers
called methyl groups (a simple group with one carbon and three hydrogen atoms,
known as CH3). At birth, DNA in the cell nucleus has a significant fraction
of its cytosine residues tagged with methyl groups. Depending on the cell
type, the level of cytosine methylation ranges from 2-6%.
Aging is regulated and programmed by the gradual loss of methyl groups from
nuclear DNA. When 40% of the methyl groups are lost, degenerative death typically
All of the factors known to cause aging accelerate the loss of methyl groups
from DNA. For example, smoking, poor nutrition, poor vitamin intake, low
exercise, environmental toxin absorption, and radiation exposure all accelerate
methyl group loss.
Any intervention that slows, stops, and reverses the loss of methyl groups
from DNA is slowing, stopping, and even reversing aging at the DNA level.
Methusalife DNA/RNA provides the most powerful laser enhanced nutrient factors
for improving DNA methylation ever studied.
The most sensitive blood chemistry test for determining the rate of methyl
group loss from DNA is called homocysteine. The higher the homocysteine level
above 4-6, the greater the rate of methyl group loss from DNA. The teenage
level of homocysteine is 4-6, which tends to rise 1-2 points per decade,
such that at 60-70, the level is typically 12-15 or higher. Elevated homocysteine
has in parallel with aging effects also been found to be a cardiac risk factor.
Above a level of 6.3, cardiac risk rises exponentially, with a level of 15
carrying a risk four times, and a level of 20 carrying a risk that is nine
times greater for a major cardiovascular incident than that of the general
In a major double blind randomized placebo controlled clinical study the
effects of laser-enhanced nutrients on homocysteine reduction and other important
metabolic factors and clinical symptoms. This study was reviewed and approved
by the Western Institutional Review Board as meeting the international standards
for the design and safety of human clinical research.
Perhaps the single most powerful homocysteine-lowering nutrient is
trimethylglycine, or TMG. This molecule has three methyl groups to donate,
hence the prefix trimethyl. It is also known as betaine because it is a natural
substance derived from sugar beets.
Previous research has shown that high dose betaine can reduce the risk of
mortality the first year after a heart attack from 25% to 0%. In addition,
high dose betaine in conjunction with vitamin cofactors has been the only
intervention that has permitted women with a genetic disease of high homocysteine
levels (homocystinuria) to conceive and have normal gestations and deliveries.
In other persons with homocystinuria, adding betaine has reversed neurologic
defects and caused gray hair to darken and lost hair to regrow.
Laser treatment of a betaine compound has shown dramatic molecular effects
that favor greater biological activity. Crystals grown using Dr. Ovokaitys'
system show a very high level of homogeneity compared to the irregularities
and numerous defects seen in control crystals grown without the laser.
Homogeneity reduces the energy required by enzymes to make the desired products.
X-ray crystallography, the gold standard for determining explicit molecular
shape since 1915, also showed striking findings. The laser treated betaine
compound had a uniform flattened and stretched shape not matched by the control
untreated molecules. The flat stretched shape has higher electric and magnetic
field moments that also promote more efficient enzymatic action.
The study formula for boosting methyl group transfers and reducing homocysteine
contained laser treated betaine as the main component. In addition laser
treated vitamin cofactors that are known to support these pathways were also
included, particularly vitamins B6, B12, and folic acid. Niacin was also
included to assist with fat metabolism in addition to homocysteine reduction,
for further cardiovascular support.
The treatment group received increasing doses of the laser enhanced methylation
formula over a 3-month period of time, whereas the placebo group only received
sugar pills. Subjects had blood drawn at baseline and every month for
homocysteine levels, blood counts, and other metabolic tests. Subjects completed
daily written reports and each week completed an extensive standardized symptom
By the completion of the study, the treatment group showed very dramatic
metabolic improvements not seen in the placebo group. Homocysteine levels
for the treatment group started at values that on average carry about double
the cardiac risk that by the end of the study reduced to values at less than
the risk of the general population. The reduction at every dosage level was
highly statistically significant, the homocysteine reduction for the group
suggestive of a 20-30 year physiologic reduction in this aging measure.
The placebo control group showed no significant change in homocysteine level.
The study compellingly demonstrated that the laser enhanced methylation formula
was the essential factor in significantly lowering homocysteine and thereby
improving methyl group transfer chemistry.
In addition to reduced homocysteine, the treated subjects also showed highly
statistically significant improvement of several clinical symptoms that included
1. Reduced anxiety
2. Decreased body aches and pains
3. Elevation of mood
4. Decreased paranoia and obsessive-compulsive scales
5. Reduced hostility
6. Much decreased global symptom profile (all symptoms taken together in
one comprehensive score)
Reducing homocysteine and improving methyl group transfers does more than
protect and repair DNA and lower cardiac risks. Thousands of published scientific
studies in the metabolic pathways related to the formula components also
suggest the following potential benefits of these nutrients:
1. Cell membrane repair
2. Increased Sam-e and serotonin levels
3. Balance of neurotransmitter chemistry in the brain
4. Increased melatonin with immunologic, antiaging, and antioxidant effects
5. Regeneration and repair of insulating myelin sheaths of nerves
6. Rejuvenating degenerating proteins into functional proteins again
7. Required for full antioxidant potency of antioxidant proteins in every
cell and tissue
8. Repair of joints and cartilage
9. Improved histamine clearance
10. Supports detoxification pathways in the liver
Methusalife DNA/RNA is further boosted in function through the addition of the
laser activated betaine and vitamin cofactors used in the clinical study.
Not only does Methusalife DNA/RNA provide the nucleic acid bases needed for
regeneration of cellular DNA, it also provides methyl group transfer factors
to help slow, stop, and turn back the aging clock at the time of DNA
These longevity-enhancing cofactors in Methusalife DNA/RNA support a vast range
of cellular balance and repair from the DNA to the cell membrane to the spaces
between the cells. With its complete spectrum of bioavailable nutrients,
Methusalife DNA/RNA is one of the most powerful health and longevity formulations
8. Added ATP Benefits
ATP stands for adenosine triphosphate, perhaps the most important of all
the nucleic acid derivatives in the body. Its effects are so powerful and
essential to cellular function, a description of its unique properties warrants
special attention. Methusalife DNA/RNA has an especially rich supply of ATP
in a highly bioavailable form.
ATP is the fundamental currency of every cell in the body. Virtually every
activity in the body that requires energy uses ATP as the source of power.
Whether the function is building complex molecules from building blocks,
maintaining the electric potential of cell membranes, or allowing muscle
fibers to contract for mobility, speed, and strength, it is ATP that provides
the electrochemical fuel.
8A. Cellular Energy
There are two fundamental ways ATP is generated in the body, one very efficient
and one very wasteful. Efficient ATP production occurs through aerobic metabolism
in the mitochondria, tiny organs or organelles within the cell that burn
fuels like fat and glucose to generate ATP. Aerobic means that oxygen is
used to completely "burn" a fuel for maximum ATP production. For example,
the complete combustion of a single glucose molecule to carbon dioxide and
water yields a rich harvest of 36 molecules of ATP. As Methusalife boosts cellular
oxygen delivery, already making ATP production more efficient, the ATP in
Methusalife DNA/RNA has an ideal environment for further boosting cellular energy
conditions; thus all the desirable ATP effects are likely to be even more
Inefficient ATP production occurs through anaerobic metabolism. Anaerobic
means without oxygen, so very little energy and ATP are extracted from fuels.
When glucose is broken down through anaerobic metabolism, each molecule of
glucose only gives rise to 2 molecules of ATP, wasting 95% of the potential
glucose energy. Further, the byproduct of this reaction is two molecules
of lactic acid, which makes the cells more acidic and less functional. In
athletes, lactic acid accumulation causes muscle fatigue and the "burn",
whereas in cancer cells lactic acidosis is a long recognized metabolic
disturbance that can promote a dwindling spiral of progressive malignancy.
The direct suppression of tumor cell lines by ATP is likely related to increased
cellular energy efficiency. The oxygenating effects of Methusalife combined
with the rich supply of ATP in Methusalife DNA/RNA is likely to be additive
and even synergistic at helping cells throughout the body achieve higher
energy potentials and more ideal energy balances.
8B. Neurologic Effects
ATP is the primary fuel that drives learning, memory, and concentration
functions. ATP is essential to maintain the membrane potentials that permit
nerves to integrate and transmit signals throughout the central and peripheral
In addition, giving ATP or its breakdown product adenosine intravenously
has shown pain relief comparable to injected morphine for pain due to ischemia
(impaired blood flow). Two surgical studies have shown a 25% reduction in
the need for postoperative narcotic pain relievers when adenosine was given
Perhaps most remarkable, peripheral neuropathic pain is one of the most difficult
pain syndromes to manage. Excruciating constant pain may resist all but the
most drastic measures. IV adenosine for 45-60 minutes reduced neuropathic
pain for 6 hours to 4 days in 86% of persons tested.
8C. Cardiac Strengthening
The cyclic contraction of cardiac muscle is highly ATP intensive and thrives
on aerobic metabolism. The combined oxygenation and ATP delivery effects
of Methusalife DNA/RNA provide the heart with an enhanced energy supply for
Providing intravenous ATP has been shown to slow conduction through the AV
node, which has been used to slow down certain excessively fast heart rated
called tachycardias. Occasionally chest symptoms can occur with rapid intravenous
infusions of ATP that resolve within seconds after stopping the infusion.
ATP is not known to cause excessively slow heart rates in persons whose heart
rates are normal.
8D. Muscle Performance
Skeletal Muscle also requires abundant quantities of ATP for muscular
contraction. Supplemental ATP has been described as an "explosive performance
enhancer." Especially if given with two other nutrient supporters of muscle
function, creatine monohydrate and creatine pyruvate, muscle endurance,
performance, and recovery can be significantly boosted.
8E. Lung Function
ATP administration has been shown to have numerous beneficial effects on
lung function, particularly the delicate lining membranes of the airways
and alveoli. In the lung, branching tubes called bronchi and then bronchioles
deliver air to and from the tiny air sacs called alveoli. The alveoli form
a large membrane only a single cell in thickness through which capillary
blood can pick up a new supply of oxygen and unload carbon dioxide with every
In vitro, or test tube level research, has shown that ATP increases secretion
of surfactant in the alveoli. Surfactant is an essential substance that keeps
the alveoli from collapsing when the breath is exhaled, preserving integrity
of functional gas exchange.
The bronchial tubes are lined with tiny brush like structures called cilia
that are constantly sweeping particulates that get into the lung upward and
outward. ATP not only increases the ciliary beat frequency, it also increases
the secretion of mucus and water from the bronchial lining, to help keep
the lungs clear at all times.
In some conditions, the blood pressure in the vessels in the lungs can rise
too high, a condition known as pulmonary hypertension. When given intravenously,
ATP binds to the lining of the pulmonary vessels and stimulates a cascade
of events that cause the blood vessels to relax and lower the pressure.
Cystic fibrosis is one of the most common inherited genetic diseases. Impaired
water and electrolyte secretion from the bronchial lining results in thick
secretions that block the bronchial tubes and result in recurring infections.
ATP has been found to increase electrolyte and water secretion with improved
clearance of secretions, offering hope of a new and useful intervention in
this often aggressively progressive condition.
8F. Cellular Immune Enhancement
Natural killer cells and cytotoxic T cells as reviewed are subtypes of effector
lymphocytes that have a vital role in immune defense against tumors and
virus-infected cells. Recent research suggests that ATP may play an important
role in the mechanism through which these effector cells eliminate the target
abnormal cells. In test tube studies, ATP has been shown to enhance the ability
of cytotoxic lymphocytes to rupture the membranes of tumor cells.
8G.ATP Test Tube Studies
In test tube studies, adding ATP has shown the ability to inhibit the growth
of several types of human cancer cell lines. The types of cancer cells inhibited
include pancreatic cancer, colon cancer, melanoma, androgen-independent prostate
cancer (i.e., not responsive to male hormone manipulation, the most aggressive
variant), breast cancer, myeloid and monocytic leukemia (bone marrow derived
tumors of blood forming cells), and multidrug resistant colon cancer. In
contrast, normal cells from these tissues showed less inhibition of growth
or no inhibition at all, suggesting that increasing ATP outside cells may
have a selective inhibitory effect on several cancer cell lines.
Mice injected with the untreated leukemia cell line L1210 died of leukemia
within 18 days. In contrast, if the leukemic cells were treated with ATP
before injection, 85% of the recipient mice survived for more than 70 days,
a highly significant increase in survival.
In mice and rats, injections of ATP into the abdominal cavity have significantly
slowed the growth of several different types of tumor cell lines, including
colon cancer, lymphomas, and breast cancer. ATP administration resulted in
significantly prolonged survival in the treated animals.
Administering ATP may also enhance the effectiveness of cancer chemotherapeutic
agents, increasing the antitumor effect of a given dose, or greatly reducing
the dose required for a therapeutic effect. In particular, decreasing the
dose of the treatment agents can dramatically reduce the toxicity of these
For example adding ATP to the drug doxorubicin to cultures of human ovarian
cancer cells doubled the tumor cells eliminated compared to using doxorubicin
alone. When ATP was given, 30-50% more doxorubicin accumulated in the cancer
cells, whereas giving ATP to healthy human cells did not increase the
accumulation of the drug.
In mouse melanoma cell lines, ATP increased the entry of several chemotherapeutic
agents. The antitumor effects of these agents were additively increased with
ATP treatment. Even more remarkable was the synergistic antitumor effect
seen with the drug vincristine; the effective therapeutic dose of this agent
was reduced to one-tenth to one-fiftieth of the dose usually required.
In mice with melanoma addition of the ATP derivative adenosine to the treatment
program significantly increased the tumor elimination. In addition, a protective
effect was seen on the healthy bone marrow, preventing the usual decrease
in white blood cells due to treatment.
Beyond growth inhibition, ATP may cause some types of tumor cells to burst.
In human acute myeloid leukemia, a dose-dependent rupture of the cancer cells
was seen using ATP.
In a randomized human clinical study, intravenous ATP was given to patients
with advanced lung cancer at 2-4 week intervals. Whereas the control patients
lost 2 pounds per month, the treated patients had stable to slightly increased
weight. Over the six months of the study, the control patients lost one third
of their muscular strength, while the ATP treated patients lost no strength.
Although some medications may maintain weight in cancer patients, this is
usually due to fat gain while muscle is lost. Intravenous ATP is the first
intervention ever studied that appears to be able to maintain muscle mass,
body weight, and muscle function in advanced cancer patients.
Thus ATP may be broadly beneficial in supporting antitumor cell biology.
ATP enhances cellular immune function, inhibits the growth of several types
of tumors, and in some cases may be able to cause direct elimination of tumor
cells. In addition, ATP protects from radiation injury and may preserve weight
and muscle strength. Further study will be needed to assess the full range
of benefits it may provide. Given its high safety profile, ATP use may be
one of the most beneficial adjuncts developed for supportive care, enhancing
the results of conventional treatments.
8H. Improved Human Survival of Shock
Under conditions of metabolic stress, such as depriving a tissue of oxygen
through reduced blood supply, a rapid and massive depletion of ATP within
cells occurs. Giving ATP or its metabolite adenosine has been described as
a "natural defense system" to protect the tissues from the effects of severe
oxygen deprivation. These protective effects include improved function of
energy generating mitochondria, better electrolyte transport, increased ATP
within cells, reduced oxygen consumption, and improved function of messenger
molecules within the cells.
Shock is a condition in which there is a generalized reduction of blood flow
and oxygenation to tissues below that required for their function. If shock
is sustained, organ failure or death may occur. Once shock is reversed,
supportive measures to assist tissue recovery can significantly affect quality
In a study of 32 patients with acute kidney failure or multiple organ failure
due to shock, highly beneficial effects of intravenous ATP were observed.
The patients were randomly divided into the treatment group that received
intravenous ATP or the control group that did not. The survival rate of 73%
in the control group was increased to 100% survival in the ATP treatment
group, showing the powerful tissue restorative effect of this intervention.
8I. Sexual Function
In human tissue studies, the administration of ATP and adenosine has been
found to induce the smooth muscle relaxation that is essential for erectile
function. In diabetic men, erectile dysfunction is common through several
mechanisms. The erectile tissue of diabetic men has been found to be especially
sensitive to the smooth muscle relaxation effects of ATP, offering them a
hopeful avenue of recovery of erectile function.
Containing both ATP and adenosine, Methusalife DNA/RNA provides these elements
known to support optimum sexual function. Whether it is delivering the nutrients
to repair and preserve the health of tissues, or boosting energy and performance,
Methusalife DNA/RNA is designed to enhance quality of life across the board.
Methusalife DNA/RNA has an outstanding safety profile. The levels of nucleic
acid elements provided falls within the internationally approved safety
guidelines for supplementing nucleic acids in infant formulas, if used as
recommended on the product label. As these guidelines are on a per kilogram
basis, the suggested adult usage is 6 sprays by mouth per day.
The one precaution is that the purine nucleic acids adenine and guanine are
metabolized to uric acid in the body. Persons with elevated uric acid or
a history of gout may have a very slightly increased risk of an episode of
gout while taking nucleic acid supplements. Because of the very high potency
and bioavailability of the nucleic acid elements in Methusalife DNA/RNA, the
specific quantities of purine bases are well below that usually associated
with an increased risk of elevating uric acid.
Methusalife has been used worldwide for decades with a superb safety profile,
even for use in children. The amino acid and vitamin cofactors added are
also known to be extremely safe. The methyl group transfer factors are not
only extremely safe; they are highly beneficial for persons of all ages.
Some persons find that they are highly energized with
Methusalife DNA/RNA and
may have difficulty falling asleep if they take it too late in the day. For
such persons it is best to use the formula earlier in the day to enjoy the
energy effects without interference with sleep.
For any person with medical issues, it is always advised that their physician
be consulted before beginning any new nutritional program.
10. Summary and Conclusion
Methusalife DNA/RNA is a landmark new formula that combines the benefits of
Methusalife with powerful proprietary laser technology. Delivering highly bioactive
nucleic acid elements with synergistic cofactors, this formula can help rebuild
and boost the function of every cell in the body.
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administered purines in rats. J Nutr 1981; 110: 1793-1804.
Uauy R, Quan R, Gil A. Role of nucleotides in intestinal development and
repair: implications for infant nutrition. J Nutr 1994; 124: 1436S-41S.
Bowles JT. The evolution of aging: a new approach to an old problem of biology.
Medical Hypotheses 1998; 51: 179-221.
Agteresch HJ, et al. Adenosine triphosphate: established and potential clinical
applications. Drugs 1999; 58(2): 211-232.
Gur S, Ozturk B. Altered relaxant response to adenosine and adenosine
5'-triphosphate in the corpus cavernosum from men and rats with diabetes.
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Borsook H, et al. Treatment of cardiac decompensation with betaine and
glycocyamine. Annals of Western Medicine and Surgery 1951; 5(10): 830-55.
Boushey CJ, et al. Quantitative assessment of plasma homocysteine as a risk
factor for vascular disease: probable benefits of increasing folic acid intakes.
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Cooney C. Methyl magic: maximum health through methylation. Andrews McNeil
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Cooney C. Are somatic cells inherently deficient in methylation metabolism?
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Frankel P. The methylation miracle: unleash your body's natural source of
SAMe. St. Martin's Mass Market Paper 1999
Kishi T, et al. Effect of betaine on SAMe levels in the cerebrospinal fluid
of a patient with methylenetetrahydrofolate reductase deficiency and peripheral
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Lee MA, et al. Study on homocysteine's role in atherosclerosis. Proceedings
of the National Academy of Sciences 1994; 91(14): 6369-73.
McCully KS. The homocysteine revolution: medicine for the next millennium.
Keats Publishing: Los Angeles, California, 1999.
McKully KS. Vascular pathology of homocysteinemia: implications for the
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Nygard O, et al. Plasma homocysteine levels and mortality in patients with
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Perry IJ, et al. Prospective study of total serum homocysteine concentration
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formula is enhanced with the patented QI Laser™ (Quantum
Information Laser) technology. Use of this process has been
associated with enhanced bioactivity of nutrients.
Amount per bottle: 30ml
Serving size: 6 sprays
Servings per container: 30
Shake bottle. Take 3 sprays under the tongue twice daily. Hold in
the mouth for 60 seconds before swallowing.
Thiamine Mononitrate (B1) 0,4mg, Niacinamide (B3) 2.5mg, Calcium
Pantothenate (B5) 5mg,
Pyridoxine Hydrochiorde (B6) 5mg, Methylcobalamin (B12) 50mg, Folic
per serving % RDA
1-D-Ribofuranosyluracil, ATP, L-Glycine, L-Glutamine, L-Serine, L-Lysine,L-Proline,
1-(2’Deoxy-B-D-Ribofuranosyl)-5-Methyl, 6-Amino-purine HCI,
1-(2’Deoxy-B-D-Ribofuranosyl) Cytosine:HCI, L-Aspartic
Ingredients:purified water, Glycerine, N&A Flavors, Soybean oil,
Xanthan Gum, Potassium Sorbate, Grapefruit Seed Extract &
RDA not established
Don’t take if you suffer from gout. Food supplements should not be used
as a substitute for a varied diet. Store out of reach of young children.
Store in a cool dry place.
Methusalife DNA/RNA 1 oz.